| ncRNA name | EGFR shRNA |
| ncRNA Category | shRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell line WERI-RB1; human embryonic kidney cell line HEK293T |
| Methods | shRNA knockdown, apoptosis analysis, cell cycle assay, transwell assay, Western blot |
| Expression pattern | associated |
| Functional description | EGFR down-regulation, through the PI3K/AKT/mTOR signaling pathway, could inhibit RB progression by promoting cell death while suppressing cell proliferation and invasion. Down-regulation of EGFR using shRNA lentiviral vectors may offer a novel non-invasive treatment for RB. |
| PubMed ID | 28852437 |
| Year | 2017 |
| Title | A novel treatment approach for retinoblastoma by targeting epithelial growth factor receptor expression with a shRNA lentiviral system. |
| Drug-related ncRNA | NA |
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